cis-Element clustering correlates with dose-dependent pro- and antisignaling effects of IL18
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Dose-dependent effects of morphine on hippocampal seizure
Opiates have complex effects on seizure thresholds as these substances have both anti and proconvulsive actions in the mammalian brain. A reduction of inhibitory synaptic activity or enhancement of excitatory synaptic activity would be expected to trigger a seizure. This study is designed to determine how morphine and naloxone affect seizures induced by a low Mg2+ perfusate in the whole, intact...
متن کاملDose-dependent effects of morphine on hippocampal seizure
Opiates have complex effects on seizure thresholds as these substances have both anti and proconvulsive actions in the mammalian brain. A reduction of inhibitory synaptic activity or enhancement of excitatory synaptic activity would be expected to trigger a seizure. This study is designed to determine how morphine and naloxone affect seizures induced by a low Mg2+ perfusate in the whole, intact...
متن کاملDose-dependent hepatotoxicity effects of Zinc oxide nanoparticles
Objective(s): Zinc oxide nanoparticles (ZNP) are increasingly used in sunscreens, biosensors, food additives and pigments. In this study the effects of ZNP on liver of rats was investigated. Materials and Methods: Experimental groups received 5, 50 and 300 mg/kg ZNP respectively for 14 days. Control group received only distilled water. ALT, AST and ALP were considered as biomarkers to ind...
متن کاملCRM1-dependent function of a cis-acting RNA export element.
Viruses often contain cis-acting RNA elements, which facilitate the posttranscriptional processing and export of their messages. These elements fall into two classes distinguished by the presence of either viral or cellular RNA binding proteins. To date, studies have indicated that the viral proteins utilize the CRM1-dependent export pathway, while the cellular factors generally function in a C...
متن کاملLa autoantigen binding to a 5' cis-element of rubella virus RNA correlates with element function in vivo.
Rubella virus genomic RNA contains a 5' stem-loop (5'(+) SL) which is required for efficient translation and replication. The La autoantigen previously was shown to bind this RNA sequence in vitro. Results reported here demonstrate that this cellular RNA-binding protein binds to the RV 5' SL RNA with sufficient specificity for the binding to occur in the presence of excess total cellular RNA. F...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2004
ISSN: 1466-4879,1476-5470
DOI: 10.1038/sj.gene.6364099